Risks of Stroke Prevention Medication

For many people who have heart conditions or a history of strokes, therapy and lifestyle changes are not enough; medication is a necessity. Stroke prevention medication saves lives.

Learning the risks of certain drugs will help to reduce the likelihood of hazardous events while you are adjusting to new stroke medication.

Types of Stroke Prevention Medications

There are two primary categories of stroke prevention medications: antiplatelet agents and anticoagulants. Both of these types of drugs work to keeps clots from forming and inhibit the growth of existing clots. They work by different mechanisms and come with varying degrees of risk.

Antiplatelet agents slow the production of thromboxane, a chemical that signals for platelets to stick together and form clots. Aspirin, clopidogrel, dipyridamole and ticlopidine are all common antiplatelet agents.

Anticoagulants target clotting factors, which are proteins made in the liver. These are recommended to patients with a high risk of stroke and atrial fibrillation (AF). Warfarin, Pradaxa, Xarelto and Eliquis are all anticoagulants.

Risks associated with Antiplatelet Agents

Not everyone will benefit from antiplatelet therapy; some people will need to take adjusted doses or use alternative medications. People with a history of the following conditions should consult their doctor before taking these drugs:

  • a history of liver disease
  • a history of kidney disease
  • high blood pressure
  • bleeding disorders
  • asthma
  • gastrointestinal diseases
  • peptic ulcers

Antiplatelet agents are also not recommended for people who have haemorrhagic  strokes (bleeding in the brain).

Risks associated with Anticoagulants

Many patients take warfarin, which has been the staple anticoagulant for decades, but they must follow strict guidelines. First, patients require regular blood tests that measure your International Normalized Ratio (INR), reflecting the time it takes for your blood to clot. Patients also have to monitor their intake of certain foods that can reduce the efficacy of warfarin.

The following foods should be monitored:

  • Broccoli
  • Kale
  • Parsley
  • Spinach, cabbage and lettuce
  • Brussels sprouts
  • Endives
  • Turnip, collard and mustard greens
  • Green onions

All of these foods contain vitamin K, which inhibits warfarin’s blood-clotting mechanism. As long as the consumption of these foods is monitored, warfarin can be used. Also, if there are bleeding emergencies that arise during warfarin use, a hospital can administer vitamin K to stop the bleeding.

Anticoagulants without Bleeding Antidotes

Pradaxa, Xarelto and Eliquis are anticoagulants –also known as blood thinners—all made available for use within the last three years. None of them has an antidote, putting users at risk for uncontrollable bleeding accidents.

Falls, small cuts, minor wounds, surgeries, internal and external bruises, and other accidents can quickly escalate into emergency situations. Even with hospitalization and medical care, some patients do not survive these events.

In 2011, there were 542 deaths related to Pradaxa use. Some of these were related to hemorrhaging , while others may have been the result of heart problems. Multiple studies have shown that Pradaxa can increase the risk of heart attack and symptoms of heart disease.

Since Xarelto and Eliquis are newer additions to the blood thinner market, reports of adverse events are yet to be gathered.

Alanna Ritchie is a content writer for Drugwatch.com. She focuses on prescription drugs, medical devices and consumer safety.

Stroke Prevention: Carotid Artery Stents vs. Medical Therapy

A new study has found that Carotid Artery Stenosis might not be as effective as medical therapy in stroke prevention. The study found that the risk of stroke after carotid artery stenting was much higher than was originally thought; and at the same time the results of medical therapy for stroke prevention were much better than they had expected.

A stroke occurs when the blood supply to the brain is cut off or significantly reduces. Doctors have been increasingly using stents, especially in patients who have already had a stroke and run the risk of a second stroke occurring in the same place as the first. Carotid artery stenting involves the insertion of a small balloon into the blocked carotid artery to open up the artery and therefore the blood supply to the brain. Previous trials have shown it is a relatively safe procedure, however, it now seems that it might not be as safe as we think.

The trial, published online on September 7th in the New England Journal of Medicine, found that carotid artery stenosis was associated with more strokes and death than medical therapy. Carotid artery stenosis is an extremely advanced surgery that requires highly trained surgeons, therefore, its success is far from guaranteed. It seems that the insertion of the stent could in fact be damaging the artery and causing a stroke. This was also found to be the case in brain stents which were damaging the blocked blood vessels in the brain upon insertion, resulting in strokes as opposed to preventing them.

Medical therapy, on the other hand,  involves aspirin, clopidogrel, management of LDL and blood pressure, to prevent strokes. This turned out to be a far safer and more effective treatment than they had thought. Therefore, perhaps medical therapy is the best option for high risk patients than carotid artery stenting which, far from preventing stroke, might actually be causing them.

Why Preventative Cardiovascular Care is Important

Heart disease is one of the biggest killers of American men and women. And while it can’t be 100% preventable, studies have shown that if the right steps are taken, risk factors can dramatically lessen.

Preventative cardiovascular care means that you go into the doctor’s office such as cardiovascular doctors panama city FL for the sake of prevention, not treatment. Every American that is at high risk now, whether it be because heart disease runs in the family or any other reason, deserves to find out what testing is out there and what preventative lifestyle choices they could make.

We know the statistics. We know the risk factors. Think about it: there’s no reason not to act.

FDA Issues Warning on Heart Drug Multaq

The FDA issued a warning today to all patients currently taking Multaq, a drug used to treat the heart condition atrial fibrillation, that they should call their doctors right away.

The PALLAS clinical study being conducted on the medication was abruptly halted due to doubled increased risks for death, stroke and heart failure in patients with atrial fibrillation.

The statement from the FDA reads:

FDA is evaluating whether and how the preliminary results of the PALLAS study apply to patients taking Multaq for paroxysmal or persistent atrial fibrillation or atrial flutter. The PALLAS study results are considered preliminary at this time because the data have not undergone quality assurance procedures and have not been completely adjudicated. FDA will update the public when more information is available

The FDA also notes that patients should not discontinue the Multaq without first talking with their healthcare providers.

Cholesterol Med Niacin May Not Help Heart Health

The National Institute of Health halted their study on cholesterol medication niacin 18 months early due to its lack of benefit on heart health. Furthermore, the study revealed, it may increase one’s risk for stroke.

“The lack of effect on cardiovascular events is unexpected and a striking contrast to the results of previous trials and observational studies,” said Jeffrey Probstfield, M.D., AIM-HIGH co-principal investigator and professor of medicine and epidemiology at the University of Washington, Seattle. “The AIM-HIGH findings do not support the trial’s hypothesis that, in the population studied, adding extended-release niacin to simvastatin in participants with well-controlled LDL cholesterol can provide additional clinical benefit.”

However, despite the study’s results, Dr. Steven Schnur, cardiologist and concierge medicine practice CEO advises that patients consult with their physicians before discontinuing their current niacin prescriptions. “The patient population in this study had well-controlled LDL [bad] cholesterol, but in many patients this is not the case,” he says. “Further studies need to be done and several studies are currently [in progress].”